|
rs25489
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a study of 1,604 incident colon cancer cases and 1,969 matched population-based controls genotyped for BER variants OGG1 (S326C) and XRCC1 (R194W, R280H, and R399Q), we found no associations with colon cancer overall.
|
19959686 |
2009 |
|
rs25487
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a study of 1,604 incident colon cancer cases and 1,969 matched population-based controls genotyped for BER variants OGG1 (S326C) and XRCC1 (R194W, R280H, and R399Q), we found no associations with colon cancer overall.
|
19959686 |
2009 |
|
rs1799782
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that the XRCC1 Arg194Trp polymorphism may modify the risk for CRC, particularly colon cancer.
|
23857281 |
2013 |
|
rs760891242
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
P125A-endostatin also localised into tumour tissue to a higher degree than the native protein, and displayed greater inhibition of growth of colon cancer in athymic mice.
|
15083196 |
2004 |
|
rs2010963
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
After stratifying by tumor molecular subtype, SNP associations observed for colon cancer were: VEGFA rs2010963 with CIMP+ colon tumors; FLT1 rs4771249 and rs7987649 with TP53; FLT1 rs3751397, rs7337610, rs7987649, and rs9513008 and KDR rs10020464, rs11941492, and rs12498529 with MSI+ and CIMP+/KRAS2-mutated tumors.
|
23794399 |
2014 |
|
rs1443465532
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
P125A-endostatin also localised into tumour tissue to a higher degree than the native protein, and displayed greater inhibition of growth of colon cancer in athymic mice.
|
15083196 |
2004 |
|
rs1222213359
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
According to our results, -1154 G/A and -460 C/T do not influence VEGF mRNA expression in colorectal tumors and susceptibility to sporadic colon cancer</span>, although the role of other polymorphisms cannot be excluded.
|
18613756 |
2008 |
|
rs11832059
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
When stratified by anatomic site, we also found statistically significant associations for three CYP24A1 polymorphisms with risk of distal colon cancer (IVS4 + 1653C > T: OR for CT/TT versus CC, 0.81; 95% CI, 0.68-0.96; IVS9 + 198T > C: OR for CC versus TT, 1.33; 95% CI, 1.03-1.73; and within whites only: +4125bp 3' of STPC > G: OR for GG versus CC, 1.44; 95% CI, 1-2.05).
|
19706847 |
2009 |
|
rs1448674651
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither MTR D919G nor RFC 80G>A polymorphisms were associated with altered colon cancer risk.
|
16284371 |
2005 |
|
rs187960998
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs187960998 in miR-211 was highly associated with a decreased risk of CC in the Chinese population by deregulating a tumor suppressive gene CHD5.
|
30655677 |
2019 |
|
rs878854066
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs760043106
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In our study, a novel germline c.584T>C (p.Ile195Thr) mutation of the p53 gene was found in a 21-year-old male with a glioblastoma and colon cancer.
|
19405127 |
2009 |
|
rs55819519
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a study of 1,604 incident colon cancer cases and 1,969 matched population-based controls genotyped for BER variants OGG1 (S326C) and XRCC1 (R194W, R280H, and R399Q), we found no associations with colon cancer overall.
|
19959686 |
2009 |
|
rs1131691029
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significant interaction between the -200A>C IGFBP3 polymorphism and the Pro12Ala PPARgamma polymorphism and risk of colon cancer (p for interaction = 0.02) with individuals being at significantly lower risk if they had both the CC IGFBP3 genotype and the PA/AA PPARgamma genotype.
|
16489531 |
2006 |
|
rs1131691014
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs1042522
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs77191406
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
More importantly, a RA patient who was heterozygous for rs77191406 developed colon cancer 10 years after the RA diagnosis.
|
27435953 |
2016 |
|
rs352144
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>TLR-9</i> rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.
|
28031717 |
2017 |
|
rs352139
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>TLR-9</i> rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.
|
28031717 |
2017 |
|
rs187084
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, significant associations between the <i>TLR-9</i> rs187084 SNP and colon cancer risk were observed in female patients only.
|
28031717 |
2017 |
|
rs4986790
|
|
Colon Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR4-D299G induces features of neoplastic progression in intestinal epithelial Caco-2 cells and associates with aggressive colon cancer in humans, implying a novel link between aberrant innate immunity and colonic cancerogenesis.
|
21920464 |
2011 |
|
rs4986790
|
|
Colon Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |
|
rs11536898
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs11721827 was associated with rectal cancer (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.02, 1.58 for AC/CC vs. AA genotype, Wald p = 0.035; adjusted p = 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68, 95% CI 0.49, 0.95 for GG vs. CC/CG and OR 0.50.
|
21792899 |
2012 |
|
rs10759932
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |
|
rs3775292
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs3775292 interacted with dietary carbohydrates to alter colon cancer risk and with dietary carbohydrates and saturated fat to alter rectal cancer risk (adjusted p = 0.064, 0.0035 and 0.025, respectively).
|
21792899 |
2012 |